University of Wisconsin Neurologically Active Drug Discussion Nursing Assignment Help

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Identify a neurologically active drug of interest. It can be from any class of drug that has an effect on the central nervous system (i.e., analgesic, anti-anxiolytic, anti-epileptic, antidepressant, etc.). Conduct an internet search and complete a short writeup including the name and general physiological effect of the drug (what is it used for?), and a description of its action at the synapse (molecular site of action and effect on synaptic function/transmission).

Expert Solution Preview

Introduction:
In this response, we will explore a neurologically active drug known as Sertraline, belonging to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline is commonly used as an antidepressant to treat various mood disorders, including major depressive disorder and anxiety disorders. Its mechanisms of action at the synapse will be discussed in detail.

Answer:

Drug of Interest: Sertraline

Physiological Effect and Clinical Use:
Sertraline is a widely prescribed medication primarily used as an antidepressant. It is part of the selective serotonin reuptake inhibitor (SSRI) class of drugs. This medication is primarily prescribed to manage major depressive disorder (MDD), panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and social anxiety disorder (SAD) among other conditions. Sertraline helps to alleviate symptoms associated with these mental health conditions, including depressed mood, anxiety, intrusive thoughts, and panic attacks.

Action at the Synapse:
Sertraline exerts its therapeutic effects by inhibiting the reuptake of serotonin neurotransmitter in the synaptic cleft. Serotonin is a chemical messenger involved in regulating mood, emotions, sleep, and appetite. By inhibiting the reuptake of serotonin, sertraline increases the availability of this neurotransmitter in the synaptic gap between nerve cells.

Specifically, sertraline selectively binds to the serotonin transporter protein, also known as SERT, located on presynaptic neurons. This binding prevents the reuptake of serotonin by blocking its transporter. Consequently, more serotonin remains in the synaptic cleft, enhancing its transmission across the synapse.

The increased concentration of serotonin in the synapse leads to prolonged activation of postsynaptic serotonin receptors, particularly the serotonin 1A (5-HT1A) and serotonin 2A (5-HT2A) receptor subtypes. The activation of these receptors modulates neuronal signaling pathways and helps regulate mood, anxiety, and other behavioral and emotional responses.

By enhancing serotonergic neurotransmission, sertraline helps to restore the balance of serotonin levels in the brain, which is often disrupted in conditions such as depression and anxiety disorders. This normalization of serotonin transmission is believed to alleviate mood disturbances and improve symptoms associated with these disorders.

In conclusion, sertraline, a selective serotonin reuptake inhibitor, is an effective neurologically active drug used in the management of various mood disorders. By inhibiting the reuptake of serotonin at the synapse, it increases the concentration of this neurotransmitter and enhances serotonergic neurotransmission, ultimately leading to improved mood and alleviation of symptoms in patients with conditions such as depression and anxiety disorders.

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